Non-isotopic Labeling Reagents and Kits
Enzo Life Sciences LPS from Salmonella abortus equi S-form (TLRGRADE™) (Ready-to-Use) (Biotin) (500µl)
Useful reagent for evaluating LPS binding and cell activation in white blood cells. Alternative name: Lipopolysaccharide from Salmonella abortus equi S-form. Formulation: Liquid. Sterile, ready-to-use solution in pyrogen-free double-distilled water. Purity: Absence of dectectable protein or DNA contaminants with agonistic TLR activity. Long Term Storage: +4°C.
Enzo Life Sciences BML-283 (25mg)
Potent (AC50 = 0.111µM) and selective (over PKM1, PKR and PKL) activator of the tumor cell specific M2 isoform of pyruvate kinase (PKM2). Pyruvate kinase is a potential target for cancer chemotherapy. A useful new tool for altering aberrant glucose metabolism in cancer cells (Warburg effect). Alternative name: NCGC00030335, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)-piperazine. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (12mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences NS 1738 (10mg). CAS: 501684-93-1
A selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR). NS 1738 exhibits cognitive enhancing effects in vivo. Alternative name: 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, alpha7 nAChR positive allosteric modulator. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO or ethanol. Long Term Storage: -80°C.
Enzo Life Sciences Bisidolylmaleimide I hydrochloride (1mg). CAS: 176504-36-2
Enhanced, water soluble form of Bisindolylmaleimide I. Alternative name: 3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO or methanol. Long Term Storage: -80°C.
Enzo Life Sciences NS 1738 (50mg). CAS: 501684-93-1
A selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR). NS 1738 exhibits cognitive enhancing effects in vivo. Alternative name: 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, alpha7 nAChR positive allosteric modulator. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO or ethanol. Long Term Storage: -80°C.
Enzo Life Sciences GSK-3beta Inhibitor XVIII (5mg). CAS: 1139875-74-3
Alternative name: 2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences TG100-115 (10mg). CAS: 677297-51-7
Alternative name: 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences BX795 (10mg). CAS: 702675-74-9
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM). Alternative name: N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (118mg/ml) or ethanol (1mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences mTOR inhibitor WYE-28 (5mg). CAS: 1062172-60-4
Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian target of rapamycin) inhibitor (IC50 = 0.08 nM). WYE-28 displays 75-fold selectivity over PI3Kα (IC50 = 6 nM). Alternative name: 4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences AZD8055 (5mg). CAS: 1009298-09-2
AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC50 of 0.8 nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. Alternative name: CCG-168, (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (93mg/ml) or ethanol (3mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences mTOR inhibitor WYE-23 (5mg). CAS: 1062169-46-3
Alternative name: 4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences TG100-115 (5mg). CAS: 677297-51-7
Alternative name: 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences PI 3K-SH2-OMT (0.5 mg)
This unique SH2 domain ligand is derived from the sequence flanking Tyr751 of the PDGF receptor. It inhibits the PI 3-kinase p85 C-terminal SH2 domain (IC50=14.2 µM). It contains the nonhydrolyzable phosphotyrosine mimetic L-O-(2-malonyl)tyrosine (OMT) and is provided as the trimethyl ester for greater cell permeability. Purity: ≥98% (TLC). Formulation: Lyophilized. Solubility: Soluble in DMSO (0.5 mg/ml) or ethanol (0.3 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences SB 590885 dihydrochloride (5mg). CAS: 405554-55-4
Selective for B-Raf against 46 other kinases. SB 590885 dihydrochloride decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Alternative name: N,N-dimethyl-2-[4-[(4E)-4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences Rac1 inhibitor (5mg). CAS: 733767-34-5
NSC 23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth. Alternative name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride. Purity: ≥99% (HPLC). Solubility: Soluble in water. Long Term Storage: -80°C.